Kombucha-Mediated Silver Nanoparticles with Fungicidal Activity Against WHO-Priority Candida Pathogens: In Vitro and Galleria mellonella Evaluation. (PubMed, Curr Issues Mol Biol) - Jun 27, 2026 - "LC-MS/MS profiling of the kombucha substrate documented a phytochemical landscape dominated by epigallocatechin (up to 122,631 µg/mL) and epigallocatechin gallate (up to 415 µg/mL), with a progressive ~80% decline in epicatechin and concomitant increases in gallic acid and chlorogenic acid across the 21-day fermentation...Co-treatment amplified total hemocyte mobilization, and K-AgNP-only larvae maintained hemocyte viability above 96% at all time points, indistinguishable from negative controls. Together, these findings demonstrate antifungal activity of K-AgNPs across the genus Candida in standardized in vitro and in vivo settings and provide justification for further investigation, including head-to-head comparison against licensed antifungals and physicochemical validation of nanoparticle stability under assay conditions."
Journal • Preclinical • Candidiasis • Infectious Disease
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Adrian Florea; Alina Mihaela Baciu; Ana-Maria Vlase; Anca Onaciu; Carmen Costache; Cristian-Silviu Moldovan; Dan Alexandru Toc; Ioana Alina Colosi; Razvan Vlad Opris; Vlad Sever Neculicioiu
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