Blue Honeysuckle (Lonicera caerulea L.) Polyphenol Extract Inhibits α-Glucosidase Activity and Modulates Glucose Transport in Caco-2 Cells. (PubMed, Molecules) - Jun 27, 2026 - "A total of 24 phenolic compounds were tentatively identified, with anthocyanins and chlorogenic acid derivatives as the major constituents...In Caco-2 cell monolayers, BHPE reduced glucose transport by up to 51.56% under simulated postprandial conditions and coordinately downregulated SGLT1 and GLUT2 mRNA expression to 0.58- and 0.51-fold, respectively. These findings extend the bioactivity profile of blue honeysuckle polyphenols from enzyme-level inhibition to functional regulation at the intestinal epithelial barrier, highlighting their potential as multi-target natural ingredients for the attenuation of postprandial hyperglycemia."
Journal • Diabetes
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Bo Li; Fei Wang; Fengfeng Li; Huifang Shen; Rui Zhao; Xinmiao Yao; Xinting Shen; Yao Wang; Ye Zhou; Zhebin Li
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