Chlorogenic Acid Ameliorates CVB3-Induced Viral Myocarditis by Suppressing Viral Replication and ZBP1-Mediated PANoptosis. (PubMed, Microorganisms) - Jun 27, 2026 - "Mechanistically, CGA treatment correlates with reduced ZBP1 expression and accelerated ZBP1 degradation involving the ubiquitin-proteasome pathway, accompanied by suppressed activation of PANoptosis markers. These findings suggest that CGA alleviates CVB3-induced myocarditis through concerted antiviral and anti-inflammatory effects, with ZBP1-mediated PANoptosis as a potential contributing mechanism."
Journal • Cardiovascular • Infectious Disease • Inflammation • Targeted Protein Degradation • IGF2BP1 • ZBP1
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Hao Wu; Haoyi Zhan; Jieqing Liu; Junbo Huang; Kaiyuan Huang; Lei Tong; Lijuan Xie; Qing Song; Yachen Wang; Yanjun Di; Zhiyun Cheng
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