Solar-simulated light-driven ROS-responsive CuₓO-TiO2-X microneedle patch for intelligent antibacterial and regenerative therapy of infected burn wounds. (PubMed, Colloids Surf B Biointerfaces) - Jun 24, 2026 - "This system consists of chlorogenic acid-based microneedles encapsulating a CuₓO-TiO2-X (TC) nanozyme heterostructure designed for synergistic antibacterial and regenerative therapy...In animal experiments, TC@MN scavenges excess ROS and promotes macrophage polarization toward the M2 phenotype thereby facilitating inflammation resolution and tissue repair under light-free conditions. Collectively, this light/dark dual-mode microneedle platform integrates photocatalytic and enzyme-mimetic functions, offering a biocompatible and intelligent strategy for the treatment of infected burn wounds."
Journal • Inflammation • Pain • CAT
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An-Ni Guo; Jing-Wei Shao; Qian Tang; Wen-Li Luo; Yuan Chen; Zhen-Hua Liu
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