Targeting the Correa's cascade of gastric cancer: the potential role of phytochemicals and autophagy modulation. (PubMed, Front Pharmacol) - Oct 11, 2026 - "In the inflammatory stage, metabolites such as berberine (an alkaloid) and chlorogenic acid (a phenolic acid) modulate autophagy by regulating the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway: upstream activation of PI3K leads to AKT phosphorylation, which subsequently inhibits the downstream autophagy-related genes Unc-51-like kinase (ULK1) and Beclin-1, while these phytochemicals can reverse this inhibition to reduce inflammatory cytokine secretion and promote ulcer healing...From a clinical translation perspective, the consistent observation that pharmacological inhibition of cytoprotective autophagy enhances phytochemical-induced apoptosis suggests a rational combination strategy: pairing a phytochemical that induces cytoprotective autophagy with an approved autophagy inhibitor such as hydroxychloroquine...These findings highlight the potential of autophagy-targeting phytochemicals as promising strategies for GC prevention and treatment, offering..."
Journal • Review • Gastric Cancer • Gastrointestinal Disorder • Oncology • Solid Tumor • Targeted Protein Degradation • BECN1 • MAP1LC3B • SQSTM1
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Fuming Yao; Hebin Zhang; Jia Ma; Jijun Zheng; Jinhao Zeng; Ruilin Li; Tingyao Wang; Xiao Ma; Yueqiang Wen
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