Microenvironment-Adaptive Dynamic Hydrogel with Hierarchical Therapeutic Functions for Infected Chronic Wound Healing. (PubMed, ACS Appl Mater Interfaces) - Jun 19, 2026 - "To achieve these functions, the hydrogel is formed via dual dynamic covalent cross-linking through Schiff base and phenylboronate ester bonds between phenylboronic acid-grafted polylysine and chlorogenic acid-grafted oxidized hyaluronic acid, followed by encapsulation of berberine (BBR) and catalase (CAT)...Based on these merits, BBR/CAT@Gel rapidly cleared infection and achieved complete epidermal regeneration with well-organized collagen deposition in a mouse model of infected chronic wounds. This work establishes a rationally designed, microenvironment-adaptive hydrogel platform that integrates hierarchical therapeutic mechanisms, offering a compelling strategy for advanced chronic wound management."
Journal • Infectious Disease • Inflammation • CAT
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Caoyun Ju; Fan Zhang; Jie Xu; Jizhong Ma; Manman Lin; Shuai Ye; Wenwen Yang; Yichen Liu; Yun Tong
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