UPLC-ESI-QToF-MS/MS profiling and anxiolytic-like effects of Simira paraensis (Baill.) Steyerm bark. (PubMed, J Pharm Biomed Anal) - Jun 17, 2026 - "SP-EMB exhibited anxiolytic-like effects in both light/dark and novel tank tests, with low acute toxicity (LD₅₀ > 400 mg·kg⁻¹) and reduced sedative effects compared to diazepam (DZP, 4 mg·kg⁻¹). Furthermore, chlorogenic acid exhibited anxiolytic effects mediated by GABAA receptors. These findings may suggest that S. paraensis is a promising alternative source of anxiolytic agents with lower sedative effects."
Journal • CNS Disorders • Epilepsy • Mood Disorders • Psychiatry
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Amanda Maria Barros Alves; Emmanuel Silva Marinho; Francisco Oiram Filho; Hélcio Silva Dos Santos; Jane Eire Silva Alencar de Menezes; Kirley Marques Canuto; Larissa Rodrigues Jales Martins; Marcia Machado Marinho; Matheus Nunes da Rocha; Nádia Elígia Nunes Pinto Paracampo; Paulo Riceli Vasconcelos Ribeiro
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