Dietary chlorogenic acid improves lipid metabolism through modulation of the gut-liver microbiota axis in hyperlipidemic mice. (PubMed, Food Funct) - Jun 17, 2026 - "At the microbial level, CGA markedly reshaped gut microbial composition by enriching Lactobacillus, Ligilactobacillus, and Bacteroides, while restoring key gut metabolites involved in lipid and glucose regulation, including L-glutathione, chenodeoxycholic acid glycine conjugate, N-acetylaspartic acid, and N-acetylcysteine. Integrative correlation analysis identified a coordinated Lactobacillus-4-methylcatechol-glycerophospholipid metabolism axis as a central mechanistic signature underlying CGA-mediated metabolic improvement. Collectively, these findings demonstrate that CGA exerts pronounced anti-hyperlipidaemic and glucose-regulatory effects by simultaneously restoring gut microbial balance, remodelling host metabolite networks, and activating IRS1/CD36 signalling pathways, supporting its potential as a promising dietary intervention for the prevention and management of metabolic disorders."
Journal • Preclinical • Dyslipidemia • Metabolic Disorders • CD36 • FABP4 • LOX • SCARB1
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Abdul Basit; Abdul Mueed; Adeeb Shehzad; Khanizadeh Shahrokh; Raheem Shahzad; Salman Khan; Tao Shutian; Wang Rong
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