Intra-articular metformin and chlorogenic acid synergistically protect against cartilage degeneration by suppressing NF-κB/NLRP3 inflammasome axis in osteoarthritis. (PubMed, Tissue Cell) - Jun 13, 2026 - "In conclusion, IA MET + CGA synergistically ameliorated structural and molecular hallmarks of OA via coordinated inhibition of NF-κB/NLRP3 inflammasome activation and pyroptosis. These findings highlight the translational potential of this dual therapy as a disease-modifying approach for OA management, pending further investigations."
Journal • Hematological Disorders • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology • IL1B • IL6 • IRF1 • NLRP3 • TNFA
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Amira E Farage; Ayman M Mahmoud; Ayman S Atiba; Mona A Abdel-Kareem; Nourhan Abd-Elrafea; Rasha A Elsisy; Reem S Alruhaimi; Sulaiman M Alnasser; Walied Abdo
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