Phytochemical composition, antioxidant potential, and enzyme inhibitory properties of Onosma thracica extracts: A comparative study of extraction methods. (PubMed, PLoS One) - Jun 11, 2026 - "LC-ESI-MS/MS analysis showed that luteolin-7-glucoside and apigenin-7-glucoside were the dominant flavonoids, while chlorogenic acid and rosmarinic acid were the major phenolic acids...Docking studies showed favorable interactions of apigenin-7-glucoside and luteolin-7-glucoside with human α-amylase, apigenin-7-glucoside and luteolin with acetylcholinesterase, and rosmarinic acid with human tyrosinase-related protein 1, suggesting that these major phenolic constituents may contribute to the observed bioactivities of O. thracica. The results demonstrate that extraction method markedly shapes the phytochemical composition and bioactivity of O. thracica, and they support further work aimed at optimizing its potential pharmacological use."
Journal • Tyrosinase • TYRP1
|
|
Bektas Tepe; Cengiz Sarikurkcu; Fevzi Bardakçi; Mamdouh Alshammari; Mohd Adnan; Mousa Alreshidi; Riadh Badraoui
|