The role of chrysanthemum phytochemicals in neural tube development: a narrative review of underlying mechanisms. (PubMed, Front Cell Dev Biol) - Jun 9, 2026 - "Beneficial effects are mediated by chlorogenic acid, Eri-7-Glc, and flavonoids via NF-κB, Nrf2/HO-1, and Wnt/β-catenin pathways, reducing oxidative stress and supporting neurulation...However, direct evidence in mammalian embryos, pregnancy pharmacokinetics, and dose-response data are lacking. Chrysanthemum shows context-dependent dual effects on neurodevelopment, underscoring the need for rigorous mechanistic and toxicological studies to guide its safe use, particularly in pregnancy."
Journal • Review • Inflammation • CASP8
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Bei Zhao; Jiaojiao Gao; Jing Wang; Li Zhang; Pinglian Sun; Xiuwei Wang; Yage Dang; Yajing Chang; Yuqing Sun; Yurong Liu
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