Chlorogenic acid attenuates LPS-induced hepatic oxidative stress in broilers by regulating cyclooxygenase-2 expression. (PubMed, Poult Sci) - Sep 25, 2026 - "Immune stress can impair growth performance and induce hepatic oxidative injury; however, the protective potential and underlying mechanisms of the dietary phenolic compound chlorogenic acid (CGA) remain unclear. Celecoxib partially reproduced the effects of CGA by reducing PTGS2 and NOX1 expression and increasing FoxO3 expression. Collectively, CGA alleviates LPS-induced hepatic oxidative stress and partially improves growth performance, potentially by suppressing a COX-2-associated NOX1-mediated pro-oxidant response and enhancing Nrf2/FoxO3/GPX1-dependent antioxidant defenses."
Journal • FOXO3 • GPX1 • PACERR • PTGS2
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Bingkun Zhang; Cai Zhang; Chengjie Zhang; Dongying Bai; Fangshen Guo; Keyuan Lei; Wenrui Zhen; Xueqing Xiao; Yanbo Ma; Yi Zhang; Yushu Zhang; Ziyue Zhao
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