Heiguteng Zhuifeng Huoluo capsule alleviates osteoarthritis associated with glycerophospholipid metabolism remodeling and PI3K/AKT/mTOR-related inflammatory signaling. (PubMed, Fitoterapia) - Sep 12, 2026 - "Representative constituents, including sinomenine, magnoflorine, gallic acid, emodin, and chlorogenic acid, attenuated 740Y-P-induced signal activation...HZHC exerts its effects through regulation of glycerophospholipid metabolism and PI3K/AKT/mTOR-associated inflammatory signaling. This study provides a multi-level pharmacological framework for understanding the anti-OA effects of HZHC."
Journal • Immunology • Inflammation • Metabolic Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatology • IL1B • IL6 • TNFA
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Chuncheng Li; Huanyu Guan; Li Xiong; Ni Zhang; Pengfei Li; Shanggao Liao; Wangxuan Zhang; Wei Li; Weidong Pan; Xuejiao Wang; Yichun Sun
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