Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram-Negative Bacterial Strains. (PubMed, Microbiologyopen) - Sep 11, 2026 - "Synergistic interactions were observed with conventional antibiotics, particularly ciprofloxacin against K. pneumoniae, reducing MIC values up to fifteen-fold, and with ampicillin against E. coli and S. aureus...LC-MS profiling identified 41 compounds, including chlorogenic acid derivatives, flavonoids, ellagic acid derivatives, and triterpenes. Acute toxicity evaluation in mice at 2000 mg/kg revealed no adverse effects. Collectively, these findings support the potential of M. elliptica as a natural antibacterial adjuvant for enhancing the effectiveness of selected antibiotics against MDR pathogens, warranting further chemical, mechanistic, and in vivo investigation."
Journal • Infectious Disease • Pneumonia
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Ana Camila Micheletti; Ana Carolina de Freitas Marques; Arthur Feliciano Camargo da Silva; Iluska Senna Bonfá Moslaves; Martha Janete Giz; Mônica Cristina Toffoli-Kadri; Nídia Cristiane Yoshida; Patrícia de Oliveira Figueiredo; Talita Vilalva Freire; Valéria Dos Santos Gonçalves
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