Integrated UHPLC-MS/MS and 16S rRNA sequencing reveals that Weiling Decoction alleviates spleen deficiency with dampness pattern diarrhea by modulating intestinal microbiota. (PubMed, 3 Biotech) - Sep 11, 2026 - "The chemical profile of WLD was characterized using UHPLC-MS/MS, which identified twenty primary bioactive compounds, including vicenin-1, inosine, and chlorogenic acid...Collectively, WLD alleviates SDDP diarrhea by modulating the intestinal microbiota and restoring the host's gastrointestinal-water-energy regulatory network; these correlative findings suggest a microbiota-associated pharmacological mechanism, providing a biotechnological basis for the "syndrome-matched" treatment of gastrointestinal disorders. The online version contains supplementary material available at https://doi.org/10.1007/s13205-026-05052-y."
Journal • Gastroenterology • Gastrointestinal Disorder • GAST
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Dandan Li; Donglin Yu; Qi Long; Qianghong Tian; Xinyu Zhang; Ying Cai; Zhoujin Tan
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