The Leaf Aqueous and Ethanolic Extracts of Tricalysia okelensis Hiern. (Rubiaceae) Reverse L-NAME-Induced Hypertension, Cardiac, and Vascular Remodeling in Rats. (PubMed, Adv Pharmacol Pharm Sci) - Sep 9, 2026 - "L-NAME administration was continued either alone or with captopril (20 mg/kg/day, p.o.), AETO, or EETO at doses of 85 and 170 mg/kg/day for another 3 consecutive weeks, while the naive group received the vehicle for 6 weeks...LC-MS/MS-based molecular networking enabled the putative annotation of several polyphenolic metabolites, including chlorogenic acid, neochlorogenic acid, rutin, quercetin derivatives, kaempferol derivatives, isorhamnetin, avicularin, and guaijaverin...AETO and EETO reversed these alterations and also inhibited L-NAME-induced immune cell infiltration, fibrosis, cardiac and vascular eNOS downregulation, and iNOS overexpression, as well as ANP upregulation in heart tissue. AETO and EETO exhibit antihypertensive and anti-remodeling effects probably by modulating the renin-angiotensin system, improving endothelial function, and reducing inflammation and fibrosis."
Journal • Preclinical • Cardiovascular • Fibrosis • Hypertension • Immunology • Inflammation • Pulmonary Arterial Hypertension • MPO • NOS3
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Ariane Falone Goumtsa; Cédric Wamba Koho; Cherif Mouhamed Moustapha Dial; Elvine Pami Nguelefack-Mbuyo; Florence Nokam; Kevin Joseph Tidgewell; Pierre Watcho; Sahar Mofidi Tabatabaei
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