Carboxyl Amidation of Chlorogenic Acid Improves Anti-Inflammatory Activity and Biosafety via Potent AKR1B1 Inhibition in LPS-Induced Macrophages. (PubMed, Molecules) - Sep 27, 2026 - "Molecular docking revealed that the newly introduced amide forms an additional hydrogen bond with ILE-260, enhancing ligand-target affinity. This carboxyl-amidation strategy simultaneously improves the cellular safety and AKR1B1 inhibitory potency of CGA, providing a rational approach for developing low-toxicity polyphenol-based anti-inflammatory leads."
Journal • Inflammation • AKR1B1 • IL6 • TNFA
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Chunmei Guang; Faliu Yang; Hongwei Hou; Huan Chen
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