Stress granules as RNA triage hubs suppress extracellular vesicle secretion under oxidative stress in cancer. (PubMed, Proc Natl Acad Sci U S A) - Jul 7, 2026 - "Pancancer transcriptomic analyses further show that Rab27A expression correlates with FOXO3a-dependent antioxidant programs, underscoring clinical relevance. These findings reveal that SGs actively reprogram RNA fate to tune vesicle output, establishing a redox-responsive mechanism by which cancer cells transiently suppress EV secretion to enhance survival."
Journal • Oncology • CD63 • FOXO3 • RAB27A
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Asami Eguchi; Chitose Oneyama; Daisuke Okuzaki; Emi Mishiro-Sato; Haruki Adachi; Mitsuyo Maeda; Takeshi Yoshida; Takuya Yoshida; Yosky Kataoka; Yue Dong
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