A layered double hydroxide nanocarrier enables YM155 delivery-induced PANoptosis and immunogenic activation in hepatocellular carcinoma. (PubMed, RSC Adv) - May 26, 2026 - "Further immune profiling revealed enhanced dendritic cell maturation, pro-inflammatory macrophage polarization, and increased cytotoxic CD8+Granzyme B+ T-cell activation within the tumor microenvironment. Collectively, this LDH-based nanotherapeutic strategy enhances YM155 efficacy by coupling Survivin inhibition with PANoptosis activation and ICD-associated immune stimulation, providing a promising platform for hepatocellular carcinoma therapy."
Journal • Hepatocellular Cancer • Oncology • Solid Tumor • ANXA5 • CALR • CASP3 • CASP8 • CD8 • GZMB • HMGB1 • NLRP3
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Huaizhi Wang; Jiali Yang; Jie Gong; Lei Cai; Li Tang; Xianxing Wang
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