Whole-genome doubling drives immune evasion by silencing antigen presentation. (PubMed, Cancer Cell) - May 9, 2026 - "PRC2 inhibition preferentially suppresses WGD+ tumor growth, enhances antigen presentation, and CD8+ T cell infiltration. Our results underscore metabolic and epigenetic alterations as critical drivers of WGD-associated immune escape."
IO biomarker • Journal • Breast Cancer • Oncology • Solid Tumor • CD8 • IFNG
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Adrian V Lee; Amatullah Tawawalla; Anthony G Letai; Benedetto DiCiaccio; Brent T Schlegel; Christina Curtis; Cristina Irene Sotomayor Vivas; Daniel D Brown; Ernesto Rojas-Jiménez; Henry W Long; Isaac S Harris; Judith Agudo; Jun Nishida; Kathleen E Houlahan; Kornelia Polyak; Laura E Stevens; Lise Mangiante; Mahmoud Aarabi; Marco Seehawer; Marie-Anne Goyette; Paloma Cejas; Pengze Yan; Pierre Foidart; Pilar Baldominos; Rahul Kumar; Rong Li; Salma Parvin; Steffi Oesterreich; TashJae Scales; Triet M Bui; Xiao-Yun Huang; Xinran Cai; Xintao Qiu; Yijia Jiang; Yingtian Xie; Zheqi Li
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