From Empiricism to Precision: Century of Paradigm Shifts in Medical Dermatology. (PubMed, Clin Dermatol) - Oct 14, 2026 - "Transformative advances include penicillin for syphilis, isotretinoin for severe acne, biologics for psoriasis, corticosteroids and rituximab for pemphigus vulgaris, targeted biologic and Janus kinase inhibitors for inflammatory and autoimmune diseases, beta-blockers for infantile hemangiomas, immunotherapy and targeted therapy for cutaneous malignancies, and Hedgehog pathway inhibitors for advanced basal cell carcinoma. These landmark therapeutic breakthroughs trace dermatology's evolution from empiric treatment toward increasingly precise, mechanism-based care. This history illustrates how scientific discovery and clinical observation can redefine the management and prognosis of dermatologic disease."
Journal • Acne Vulgaris • Alopecia • Atopic Dermatitis • Basal Cell Carcinoma • Dermatitis • Dermatology • Immunology • Infectious Disease • Melanoma • Non-melanoma Skin Cancer • Oncology • Pemphigus Vulgaris • Psoriasis • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma • Vitiligo
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Jacob Beer; Jane M Grant-Kels; Marina Landua; Mohamad Goldust; Tanya Boghosian
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