FIBRONECTIN– INTEGRIN α5β1 CROSSTALK IS A THERAPEUTIC EPITHELIAL-IMMUNE AXIS IN BILIARY ATRESIA (AASLD 2026) - Oct 6, 2026 - Abstract #269; "Fn-dependent signaling was inhibited with RGDS, whereas integrin α5β1 signaling was blocked with volociximab to distinguish ligand-level from receptor-level regulation; IL-1β and IL-8 were quantified by flow cytometry... BA cholangiocytes activate macrophages through Fnintegrin α5β1 signaling. Blocking this epithelial-immune axis reduced macrophage cytokine production and bile duct obstruction, identifying integrin α5β1 signaling as a translational strategy to reduce immune-mediated injury in BA."
Cholestasis • Hepatology • Inflammation • Rotavirus Infections • CXCL8 • IL1B • ITGA5 • ITGB1
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Wenqi Li1; Nithyananthan Subramaniyam1; Reena Mourya1; Jorge Bezerra1; Pranavkumar Shivakumar1
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