Current and Emerging Therapies in Primary Vitreoretinal Lymphoma: A Narrative Review. (PubMed, Cancers (Basel)) - Sep 16, 2026 - "Search terms included "primary vitreoretinal lymphoma", "intravitreal methotrexate", "rituximab", "radiotherapy", "targeted therapy", and "immunotherapy"...Agents such as Bruton's tyrosine kinase inhibitors, immunomodulatory drugs, and immune checkpoint inhibitors have demonstrated promising results in early clinical studies, particularly in relapsed or refractory disease. Despite advances in diagnostic techniques, the management of PVRL remains challenging due to its heterogeneous presentation, high relapse rates, and frequent progression to CNS involvement."
IO biomarker • Journal • Review • CNS Lymphoma • Hematological Malignancies • Lymphoma • Oncology • Primary Vitreoretinal Lymphoma • IL10 • MYD88
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Ioana Tofolean; Radu Burcea; Suher Abduraman
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