Real-world safety and efficacy of lecanemab in the treatment of Alzheimer's disease: a systematic review and meta-analysis. (PubMed, J Neurol) - Oct 23, 2026 - "This is the first large-scale systematic review and meta-analysis of real-world studies of lecanemab reporting safety and efficacy outcomes. Safety outcomes particularly ARIA may be influenced by APOE ε4 genotype and baseline microbleeds. Cognitive outcomes lacking control data cannot confirm efficacy and longer-term cross-regional controlled studies are needed."
Clinical • Journal • Real-world evidence • Retrospective data • Review • Alzheimer's Disease • CNS Disorders • Hematological Disorders • APOE
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Jianzhun Chen; Jie Liu; Kangfu Yin; Liuhui Zhu; Xinglong Yang; Yunfeng Wu
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