A microdosimetric analysis correlating DNA damage and apoptosis in LNCaP cells following treatment with [¹⁷⁷Lu]Lu-PSMA-617 (EANM 2026) - Sep 29, 2026 - Abstract #EPS-015; Pres time: Oct 18, 2026; 08:00 AM - 09:30 AM; Location: Hall G2; "In-vitro analysis shows an increase of DSB foci and early apoptosis with increasing cellular absorbed dose. The delayed onset of apoptosis at comparatively higher absorbed dose levels confirms the good reparative potential of β-induced damage in the range of low absorbed doses. Apoptosis levels will also be measured after a 48 h recovery period to capture delayed cell death in LNCaP cells."
Genito-urinary Cancer • Prostate Cancer • Solid Tumor • ANXA5 • TP53BP1
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P. Hawarihewa 1; S. Resch 1; M. Rumiantcev 1; H. Scherthan 2; M. Zacherl 1; F. Lindheimer 1; G. Böning 1; R. A. Werner 1, 3; S. I. Ziegler 4; M. Brendel 1, 5, 6; A. Delker 1
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