Spheroid-based binding kinetics, diffusion and dosimetry of radiopharmaceuticals (EANM 2026) - Sep 29, 2026 - Abstract #EPS-016; Pres time: Oct 18, 2026; 08:00 AM - 09:30 AM; Location: Hall G2; "This method was verified across multiple cell lines (HCT116, ZR-75-1, IMR-32) and ligands (cetuximab, epidermal growth factor, trastuzumab, DOTA-Tyr3-octreotate) labeled with 125I, 177Lu or fluorescence. These results have expanded the available methodology to study ligand penetration and dose distribution in spheroids. A deeper understanding of binding/diffusion-dose relationships in spheroids can guide the optimization of existing and emerging targeted radionuclide therapies."
Solid Tumor • EGFR
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S. Lundsten Salomonsson 1, 2; G. Garrido-Hernandez 3, 4; H. Ögren 1; M. Konijnenberg 3; J. Nonnekens 3, 4
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