Decoding phillygenin's dual attack on breast cancer: ferroptosis induction and immune evasion suppression. (PubMed, J Mol Histol) - Jul 23, 2025 - "PHI elevated intracellular Fe2+ levels, an effect synergistically enhanced by erastin but attenuated by ferrostatin-1...PHI decreased tumor size and mass, lowered GPX4, p-AKT/AKT, p-GSK3β/GSK3β, and β-catenin levels, and elevated IFN-γ levels in MDA-MB-231 xenograft models. PHI inhibited BC cell proliferation and immune evasion while promoting ferroptosis through suppression of the AKT/β-catenin axis, highlighting its possible as a therapeutic agent for BC."
IO biomarker • Journal • Breast Cancer • Oncology • Solid Tumor • CD8 • CTNNB1 • GPX4 • IFNG • IL2 • PD-L1 • SLC7A11
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Jiayu Peng; JingHeng Zhang; Ruie Li; Xiaohong Lu; Yafei Li; Yan Zhang
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