TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function. (PubMed, Clin Ophthalmol) - Jul 22, 2025 - "The role of TRAP1 in ferroptosis in ARPE-19 cells was evaluated with or without ferrostatin-1 (Fer-1) and erastin...Reduced levels of TRAP1 may play a crucial role as an early contributor to mitochondrial dysfunction in diabetic retinopathy. Furthermore, the association of TRAP1 with ferroptosis improves cellular viability by enhancing mitochondrial resilience against high glucose-induced stressors and preventing cellular ferroptosis."
Journal • Diabetes • Diabetic Retinopathy • Metabolic Disorders • Oncology • Retinal Disorders • ACSL1 • ACSL4 • CYB5A • TNFA
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Guiyang Zhao; Haoshen Hu; Lixun Chen; Liyuan Wang; Qianming Du; Weida Xu; Xueteng Hu; Yidan Xu; Yuchen Guo; Yuchen Li; Yuxiang Fei
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