Gastrodia protects HT22 cells from damage caused by oxygen glucose deprivation and reperfusion through inhibiting ferroptosis. (PubMed, Sci Rep) - May 28, 2025 - "Ferroptosis inducer Erastin (Era, 10µM) successfully induced ferroptosis in HT22 cells, while Gas treatment attenuated the effect of Era. Era further promoted OGD/R-induced damage and ferroptosis in HT22 cells, whereas Gas inhibited the effect of Era. In conclusion, Gas might provide protection against induced HT22 cell injury caused by OGD/R through inhibiting ferroptosis, shows promising potential for clinical treatment of cerebral ischemia/reperfusion."
Journal • Cardiovascular • CNS Disorders • Reperfusion Injury • ACSL4 • GPX4 • SLC7A11
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Dongyue Zhou; Hui Li; Jian Liu; Jinlong Tan; Yangwen Ai; Zhixuan Huang
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