Tissue Inhibitor of Metalloproteinase 1 promotes ferroptosis and suppresses prostate cancer metastasis. (PubMed, J Biol Chem) - Apr 5, 2025 - "In comparison with TIMP1-overexpressing cells, TIMP1-knockdown cells demonstrated a 12.3% decrease in Fe2+ concentration after erastin treatment, a 37.8% reduction in malondialdehyde (MDA) levels, an 113.7% increase in GPX4 expression, and a 78.9% rise in the GSH/GSSG ratio. Our findings indicate that TIMP1 overexpression promotes ferroptosis by modulating critical markers such as GPX4 and TFRC, thereby significantly reducing metastatic potential in prostate cancer cells. Our results highlight TIMP1's role in regulating ferroptosis pathways, which are crucial for tumor progression, and exposes a potential therapeutic target for prostate cancer management."
Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • GPX4 • TIMP1
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Aicui Ma; Fen Wang; Han Yan; Jianyan Yan; Jun Guo; Junfang Zhang; Lei Li; Li Xu; Lifen Chen; Qi Pan; Shunheng Yao; Siyu Liu; Xiaoyan Mao; Yuliang Rao; Zhonghui Wang; Zuyue Sun
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