Developing a Physiologically Relevant Cell Model of Ferroptosis in Cardiomyocytes. (PubMed, Free Radic Biol Med) - Apr 5, 2025 - "Ferroptosis is commonly induced experimentally using chemical inhibitors such as RSL3 (a GPX4 inhibitor) or erastin (an inhibitor of the cystine-glutamate exchanger, Xc-) or by cysteine deprivation. This physiologically relevant system provides a robust platform for investigating therapeutic interventions targeting iron-induced oxidative stress and ferroptosis, particularly in conditions characterized by pathological iron accumulation, such as cardiomyopathies and ischemia-reperfusion injury. By focusing on the intrinsic drivers of ferroptosis, this work lays the groundwork for developing targeted treatments to mitigate ferroptosis-associated cellular damage."
Journal • Cardiomyopathy • Cardiovascular • Hematological Disorders • Reperfusion Injury • GPX4
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Ivana Chaves-Negrón; Jason N Bazil; Jorge García-Báez; Sabzali Javadov; Xavier R Chapa-Dubocq
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