Divergent ferroptotic pathways in breast cancer cells: IGFBP6-regulated mitochondrial lipid peroxidation under erastin and omega-3 DHA treatment. (PubMed, Biochimie) - Apr 4, 2025 - "Interestingly, our kinetic analysis of ferroptosis induction showed that IGFBP6 knockdown cells began to die earlier and could hardly be rescued from erastin-induced ferroptosis by mitochondrial antioxidant SkQ1, in contrast to control cells. Overall, our data suggest that the action of DHA is less dependent on mitochondrial membrane peroxidation during ferroptosis induction and this molecule can be a promising candidate for the treatment of breast cancer, especially in the case of reduced IGFBP6 gene expression in cancer cells."
Journal • Breast Cancer • Oncology • Solid Tumor • IGFBP6
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Alexander Tonevitsky; Alexandra Razumovskaya; Artem Fatkulin; Darya Averinskaya; Darya Olkhovik; Karina Klycheva; Mariia Silkina; Oksana Kolodeeva; Olga Kolodeeva; Sergey Nikulin; Timur Kulagin
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