Expulsion of iron-rich ferritin via CD63-mediated exosome drives ferroptosis resistance in ovarian cancer cells. (PubMed, Front Cell Dev Biol) - Apr 3, 2025 - "Overall, our results indicate that OVCA cells can utilize CD63+ EVs to secrete iron-rich ferritin as a mechanism to evade erastin-induced ferroptosis. These findings suggest that combining erastin with EV inhibitors could offer promising strategy for overcoming ferroptosis resistance in OVCA."
Journal • Oncology • Ovarian Cancer • Solid Tumor • CD63 • CD9 • TFRC
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Alessandro Sacco; Ana Rita Cruz; Anna Martina Battaglia; Bruno Costa-Silva; Catarina Esteves Pereira; Claudia De Vitis; Emanuele Giorgio; Flavia Biamonte; Julia Elzanowska; Lavinia Petriaggi; Luca Palazzo; Luís Rocha; Maria Carolina Strano Moraes
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