Asperosaponin VI suppresses ferroptosis in chondrocytes and ameliorates osteoarthritis by modulating the Nrf2/GPX4/HO-1 signaling pathway. (PubMed, Front Pharmacol) - Mar 17, 2025 - "Mechanistic studies revealed that ML385-induced inhibition of the Nrf2 signaling pathway reversed the increase in GPX4 and ACSL4 expression and increased Fe2+ and MDA levels; treatment with erastin, a ferroptosis inducer, produced comparable results...Our findings suggest that AVI is a promising therapeutic agent for OA. It exerted its protective effect by regulating the Nrf2/GPX4/HO-1 signaling axis to inhibit cartilage cell ferroptosis and improve osteoarthritis."
Journal • Immunology • Osteoarthritis • Pain • Rheumatology • ACSL4 • GPX4 • IL1B • IL6 • MMP13 • TNFA
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Daotong Yuan; Wenjie Chang; Wenpeng Xie; Ximin Jin; Yongkui Zhang; Zhimeng Zhang
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