CHEMICAL INDUCERS AND INHIBITORS OF FERROPTOSIS CAN ALTER THE PATHOLOGICAL EFFECTS OF ALPHA -SYNUCLEIN OLIGOMERS. (ADPD 2025) - Mar 11, 2025 - Abstract #SHIFT 01-033; Pres time: Apr 2, 2025; Location: SHIFT 01; "The ferroptosis inducer erastin, and the ferroptosis inhibitor ferrostatin -1, were used to evaluate the effect of ferroptosis induction and inhibition in HEPG2 cells... Our results demonstrate that ferroptosis inhibition may decrease the seeding capacity and the prion -like propagation effect of alpha -synuclein oligomers. Also, the induction of ferroptosis may facilitate the formation of amyloid -like aggregates in cell models even at subtoxic concentrations. These results show that ferroptosis can contribute to disease pathology through different mechanisms and that the manipulation of ferroptosis can be a viable option in developing disease -modifying treatments for Parkinson's disease and other synucleinopathies."
CNS Disorders • Movement Disorders • Parkinson's Disease
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Omer Wisam Mohammed Salih Al -Ani1; David Smith2
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