Metabolic Nanoregulators Induce Ferroptosis and Change Metabolite Flow to Reverse Immunosuppressive Tumor Microenvironment. (PubMed, ACS Nano) - Dec 12, 2024 - "By delivery of adapalene and erastin simultaneously through nanoparticles, the material and energy metabolism of tumor cells can be regulated. This nanoparticle construction achieves tumor tissue targeting and responsive drug release, alters metabolite flow within tumor cells, and effectively kills tumor cells. Additionally, the nanoparticles can reverse the tumor immunosuppressive microenvironment, starting from single-cell regulation to whole-lesion control."
Biomarker • Journal • Tumor microenvironment • Oncology
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Chen Jiang; Chufeng Li; Haolin Song; Qinjun Chen; Tao Sun; Xuwen Li; Yangqi Qu; Yifan Luo; Yiwen Zhang; Yu Wang
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