Sulfiredoxin-1 Accelerates Erastin-Induced Ferroptosis in HT-22 Hippocampal Neurons by Driving Heme Oxygenase-1 Activation. (PubMed, Free Radic Biol Med) - Aug 20, 2024 - "These results indicate that SRXN1 is a key regulator of ferroptosis, activating the HO-1 protein through cellular redox regulation, ferrous iron accumulation, and autophagy in HT-22 cells. These findings elucidate a novel molecular mechanism of erastin-induced ferroptosis sensitivity and suggest that SRXN1-HO-1-autophagy-dependent ferroptosis serves as a promising treatment approach for neurodegenerative diseases."
Journal • CNS Disorders • HMOX1
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Dongxu Zhang; Ruqian Zhao; Shihui Guo; Wenqiang Ma; Xuanfu Wu; Yingdong Ni; Yingying Dong; Yujia Shu
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