Tenecteplase for anterior-circulation vessel occlusion at 4.5-24 hours across reperfusion paradigms: A meta-analysis. (PubMed, Neuroradiol J) - Sep 9, 2026 - "Bayesian analyses yielded estimates favoring TNK for excellent functional outcome (OR 1.29, 95% CrI 1.10-1.51) but also suggested increased risks of symptomatic intracranial hemorrhage (OR 1.79, 95% CrI 1.15-2.76) and parenchymal hematoma (OR 2.02, 95% CrI 1.14-3.47); these findings should be interpreted cautiously given their dependence on Bayesian model assumptions.ConclusionAcross heterogeneous reperfusion paradigms, TNK-containing strategies showed no consistent functional benefit, while hemorrhagic outcomes raised a potential safety signal. Pooled estimates should not be interpreted as a uniform treatment effect."
Journal • Retrospective data • Review • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Ischemic stroke
|
|
Adam A Dmytriw; Gabriel Caruso Novaes Tudella; João Victor de Oliveira Ramos; João Vitor Andrade Fernandes; Leonardo Reischoffer do Nascimento; Mohamad Abdalkader
|