Neuroprotective effects of empagliflozin and metformin combined therapy on rotenone induced Parkinsonism in Wistar rats via PI3K and PPARγ modulation. (PubMed, Sci Rep) - Sep 10, 2026 - "Additionally, the combined treatment restored PI3K/AKT signaling activity and significantly upregulated PPAR-γ expression (p < 0.001 vs. ROT). Collectively, these findings suggest that combined metformin and empagliflozin therapy exerts enhanced neuroprotective effects through modulation of protein aggregation pathways, highlighting a promising drug-repositioning strategy for Parkinsonism."
Journal • Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease • PPARA • PPARG
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Al-Shimaa A Ahmed; Hany M Borg; Marwa M Mona; Sanad S El-Kholy; Shimaa A Abass
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