Integrated multi-omics reveals acylcarnitine accumulation as an early driver of doxorubicin-induced cardiotoxicity targeted by chlorogenic acid. (PubMed, Front Pharmacol) - Aug 15, 2026 - "Impaired FAO and the subsequent accumulation of toxic acylcarnitines serve as early drivers of DOX-induced metabolic dysfunction. Targeting this lipid metabolic dysregulation with CGA represents a promising therapeutic strategy for mitigating anthracycline-induced cardiotoxicity."
Journal • Cardiovascular • Metabolic Disorders • PPARA
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Bing Wang; Guangdong Li; Huiying Sha; Jing Ren; Ning Cui; Taoyan Liu; Yibo Yang; Yin Wang
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