Qingre Chushi decoction ameliorates MC903-induced atopic dermatitis in association with reduced JAK-STAT6 activation and decreased CD206+IL-31+ macrophage abundance. (PubMed, Fitoterapia) - Oct 16, 2026 - "The chemical profile of QRCSD was characterized by UPLC-Q-TOF-MS/MS, and four representative marker compounds, including chlorogenic acid, gentiopicroside, baicalin, and glycyrrhizic acid, were quantitatively determined by targeted UPLC-MS/MS in MRM mode for quality control. Collectively, QRCSD ameliorated MC903-induced AD and was associated with restored epidermal barrier function, altered systemic and cutaneous immune responses, reduced CD206+IL-31+ macrophage abundance, and decreased JAK-STAT6 pathway activation. These findings provide a biological basis for the immunoregulatory effects of QRCSD in AD."
Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immune Modulation • Immunology • FLG • IFNG • IL13 • IL17A • IL4 • IL6 • JAK1 • JAK3 • MRC1 • STAT6 • TNFA • TSLP
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Haoyue Zhu; Huike Ma; Jingxia Zhao; Lijiaming Zhou; Ping Li; Tingting Di; Wenbo Liu; Xiaohan Yu; Yan Wang; Yueyue Ma; Yujiao Meng
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