Pharmacological modulation of triglyceride metabolism rescues energy deficits caused by neuronal TDP-43 deficiency (CINP 2026) - Jun 27, 2026 - Pres time: Jun 27, 2026; 04:00 PM - 04:30 PM; Location: Poster Area; "Pharmacological modulation was performed using chlorogenic acid in vivo, while triglyceride heptanoate supplementation was applied to neuronal cultures to assess effects on neuronal viability... These findings demonstrate that neuronal TDP-43 deficiency induces a disruption of triglyceride catabolism and energy metabolism, contributing to neurodegenerative vulnerability. Pharmacological modulation of lipid metabolism effectively improves energy supply and neuronal viability in TDP-43–deficient models. Targeting metabolic pathways may therefore represent a promising neuropharmacological strategy for TDP-43–associated neurodegenerative disorders."
CNS Disorders • Metabolic Disorders • TARDBP
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T. Zhang1; K. Yan2; Q. Liao1; J. Zhou1; Y. Liu1; F. Bi1,2
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