The radiobiological effects of FAP-targeted radionuclide therapy on patient-derived cancer-associated fibroblasts (EANM 2026) - Sep 29, 2026 - Abstract #EP-0084; "FAP-TRT using FAP-2286 induces cell death in 3T3-FAP cells, while in more physiologically relevant patient-derived CAFs, senescence is induced rather than cell death. This indicates that the radiobiological effects of FAP-TRT depend on the model system. In ongoing work, additional functional alterations of CAFs upon FAP-TRT are studied, as well as the therapeutic potential of alpha-emitters."
Clinical • Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • CAFs • FAP
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M. Moers; K. Raaijmakers; M. Boswinkel; S. Heskamp; H. Westdorp; M. Ansems; S. van Lith
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